SURVEY OF ANTI-THYROGLOBULIN CONCENTRATION IN PATIENTS WITH PAPILLARY THYROID CARCINOMA AFTER TOTAL THYROIDECTOMY
Keywords:
papillary thyroid carcinoma, anti thyroglobulin, total thyroidectomyAbstract
Objectives: This study aims to evaluate the value of Anti-Thyroglobulin (TgAb) levels after total thyroidectomy and examine the relationship between serum TgAb levels and thyroid cancer stages in patients with papillary thyroid carcinoma (PTC). Methods: Retrospective study of 160 papillary thyroid cancer patients after total thyroidectomy from 01/2023 to 07/2024 at Cho Ray Hospital. Results: The median TgAb level decreased significantly (p<0.05) from 3.26 IU/mL before radioiodine therapy to 1.50 IU/mL after treatment. Among patients with isolated PTC, TgAb concentrations were markedly lower (2.19 IU/mL) compared with those who had concomitant PTC and HT (42 IU/mL) with p<0.05. Before radioiodine therapy, 141 patients (88.13%) had TgAb levels within the normal range, and the number of patients with normalized TgAb levels increased to 144 (90%) after treatment, with no statistically significant difference (p>0.05). Conclusion: Among patients with isolated PTC, a proportion demonstrated elevated TgAb levels whereas the majority of patients with PTC accompanied by thyroiditis exhibited low TgAb concentrations
References
1. La Vecchia C, Malvezzi M, Bosetti Cea. Thyroid cancer mortality and incidence: a global overview. Int J Cancer. May 1 2015;136(9):2187-95. DOI:10.1002/ijc.29251.
2. Baloch ZW, Asa SL, Barletta JA, et al. Overview of the 2022 WHO Classification of Thyroid Neoplasms. Endocrine pathology. Mar 2022;33(1):27-63. DOI:10.1007/s12022-022-09707-3.
3. Bộ Y Tế. Thông tư số 1514/QĐ-BYT ban hành ngày 01/04/2020 về tài liệu chuyên môn "Hướng dẫn chẩn đoán và điều trị một số bệnh ung bướu". Hà Nội: Nhà xuất bản Hà Nội; 2020.
4. Rosario PW, Côrtes MCS, Franco Mourão G. Follow-up of patients with thyroid cancer and antithyroglobulin antibodies: a review for clinicians. Endocrine-related cancer. Apr 2021;28(4):R111-r119. DOI:10.1530/erc-21-0012.
5. Wu X, Lun Y, Jiang Hea. Coexistence of thyroglobulin antibodies and thyroid peroxidase antibodies correlates with elevated thyroid-stimulating hormone level and advanced tumor stage of papillary thyroid cancer. Endocrine. Aug 2014;46(3):554-60. DOI:10.1007/s12020-013-0121-x.
6. Nguyễn Thị Xuân. Hướng dẫn chẩn đoán và điều trị bệnh nội tiết-chuyển hoá. Y học; 2015.
7. Battistella E, Pomba L, Costantini A, et al. Hashimoto's Thyroiditis and Papillary Cancer Thyroid Coexistence Exerts a Protective Effect: a Single Centre Experience. Indian journal of surgical oncology. Mar 2022;13(1):164-168. DOI:10.1007/s13193-022-01515-9.
8. Lai Y, Gu Y, Yu M, et al. Thyroglobulin antibody (TgAb) positive is an independent risk factor for Lymph Node Metastasis in patients with differentiated thyroid carcinoma. International journal of general medicine. 2023:5979-5988. DOI:10.2147/ijgm.s439919
9. Sanjari M, Ordooei M, Amirkhosravi L, et al. The effect of positive thyroglobulin antibodies on the prognosis and treatment response in patients with papillary thyroid carcinoma. Heliyon. Feb 29 2024;10(4):e26092. DOI:10.1016/j.heliyon.2024.e26092.
10. Liang J, Zeng W, Fang Fea. Clinical analysis of Hashimoto thyroiditis coexistent with papillary thyroid cancer in 1392 patients. Acta Otorhinolaryngologica Italica. 2017;37(5):393. DOI:10.14639/0392-100X-1709
11. Trần Thị Minh Nguyên, Hồ Thị Tuyết Thu, Ngô Thị Tuyết và cộng sự. Khảo sát nồng độ Anti Thyroglobulin huyết tương trong theo dõi người bệnh ung thư tuyến giáp thể biệt hóa có phẫu thuật kết hợp điều trị I-131 tại Bệnh viện Ung Bướu Đà Nẵng. Tạp chí Y Dược Học Cần Thơ. 2023;(58):181-186. DOI:10.58490/ctump.2023i58.709
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